| Identification | Back Directory | [Name]
N,N-DiMethyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-ethanaMine | [CAS]
877149-80-9 | [Synonyms]
N,N-Dimethyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)
1-[2-(Dimethylamino)ethyl]-1H-pyrazole-4-boronic Acid Pinacol Ester
(1-(2-(dimethylamino)ethyl)-1H-pyrazol-4-yl)boronic acid pinacol ester
diMethyl({2-[4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]ethyl})aMine
N,N-DiMethyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-ethanaMine
N,N-dimethyl-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]ethanamine
1H-Pyrazole-1-ethanaMine, N,N-diMethyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-
N,N-diMethyl-2-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethanaMine
N,N-dimethyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethan-1-amine | [Molecular Formula]
C13H24BN3O2 | [MDL Number]
MFCD16660235 | [MOL File]
877149-80-9.mol | [Molecular Weight]
265.16 |
| Chemical Properties | Back Directory | [Boiling point ]
365.8±22.0 °C(Predicted) | [density ]
1.04±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [pka]
8.93±0.28(Predicted) | [Appearance]
Colorless to light yellow Liquid |
| Hazard Information | Back Directory | [Synthesis]
The reaction mixture was suspended in acetonitrile (30 mL) in the presence of cesium carbonate (6.72 g, 20.61 mmol) using 4-pyrazolylboronic acid pinacol ester (2 g, 10.31 mmol) and dimethylaminoethyl chloride hydrochloride (2.227 g, 15.46 mmol). The mixture was heated to reflux for 5 hours and then cooled to room temperature. The reaction solution was diluted with ether and filtered, and the filtrate was concentrated in vacuum to afford N,N-dimethyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethanamine (2.61 g, 9.84 mmol, 95% yield) as an amber colored oil, which was used directly in the next step of the reaction. | [References]
[1] Patent: WO2011/54841, 2011, A1. Location in patent: Page/Page column 105
[2] Patent: US2014/45814, 2014, A1. Location in patent: Paragraph 0257; 0258
[3] Patent: WO2017/178416, 2017, A1. Location in patent: Page/Page column 116; 117
[4] Patent: WO2018/73602, 2018, A1. Location in patent: Page/Page column 99
[5] Patent: US2012/208798, 2012, A1. Location in patent: Page/Page column 47 |
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