| Identification | Back Directory | [Name]
JNJ-26990990 | [CAS]
877316-38-6 | [Synonyms]
JNJ-26990990
JNJ26990990,JNJ 26990990
JNJ-26990990, 10 mM in DMSO
(Benzo(b)thien-3-ylmethyl)-sulfamide
SulfaMide, N-(benzo[b]thien-3-ylMethyl)-
3-[(sulfamoylamino)methyl]-1-benzothiophene | [Molecular Formula]
C9H10N2O2S2 | [MDL Number]
MFCD18782634 | [MOL File]
877316-38-6.mol | [Molecular Weight]
242.318 |
| Hazard Information | Back Directory | [Uses]
JNJ-26990990 is a broad-spectrum antiepileptic agent with oral activity. JNJ-26990990 can inhibit voltage-gated Na+ channels and N-type Ca2+ channels, but has a very weak inhibitory effect on human carbonic anhydrase-II (IC50 = 110 μM)[1]. | [References]
[1] Parker MH, et al. Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies. J Med Chem. 2009;52(23):7528-7536. DOI:10.1021/jm801432r |
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