| Identification | Back Directory | [Name]
LtaS-IN-1 | [CAS]
877950-01-1 | [Synonyms]
LtaS-IN-1
Naphtho[2,1-b]furan-1-acetic acid, 2-oxo-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)amino]ethyl ester | [Molecular Formula]
C24H17N3O5 | [MDL Number]
MFCD07848052 | [MOL File]
877950-01-1.mol | [Molecular Weight]
427.41 |
| Chemical Properties | Back Directory | [density ]
1.400±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
9.67±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
LtaS-IN-1 (compound 1771) is a potent small-molecule inhibitor of Lipoteichoic acid (LTA) synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 alone inhibits Enterococcus.spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 combination with antibiotics abolishs multidrug-resistant E. faecium growth almost completely[1]. | [References]
[1] Paganelli FL, et al. Lipoteichoic acid synthesis inhibition in combination with antibiotics abrogates growth of multidrug-resistant Enterococcus faecium.Int J Antimicrob Agents.?2017?Mar;49(3):355-363. DOI:10.1016/j.ijantimicag.2016.12.002 |
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MedChemExpress
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