| Identification | Back Directory | [Name]
1-Decen-3-one, 1-(4-hydroxy-3-Methoxyphenyl)-, (1E)- | [CAS]
878006-06-5 | [Synonyms]
(E)-[6]-Dehydroparadol
1-Decen-3-one, 1-(4-hydroxy-3-Methoxyphenyl)-, (1E)- | [Molecular Formula]
C17H24O3 | [MOL File]
878006-06-5.mol | [Molecular Weight]
276.37 |
| Chemical Properties | Back Directory | [Boiling point ]
423.2±30.0 °C(Predicted) | [density ]
1.040±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 140 mg/mL (506.57 mM) | [form ]
Solid | [pka]
9.76±0.31(Predicted) | [color ]
Yellow to orange |
| Hazard Information | Back Directory | [Uses]
(E)-[6]-Dehydroparadol, an oxidative metabolite of [6]-Shogaol (HY-14616), is a potent Nrf2 activator. (E)-[6]-Dehydroparadol can inhibit the growth and induce the apoptosis of human cancer cells[1][2]. | [in vivo]
(E)-[6]-Dehydroparadol (compound 19) (5 μM; 24 h) enhances Tg[glutathione S-transferase pi 1 (gstp1):green fluorescent protein (GFP)] fluorescence signal in the Tg(gstp1:GFP) transgenic zebrafish embryos[2]. | [storage]
Store at -20°C | [References]
[1] Chen H, et, al. Metabolism of ginger component [6]-shogaol in liver microsomes from mouse, rat, dog, monkey, and human. Mol Nutr Food Res. 2013 May;57(5):865-76. DOI:10.1002/mnfr.201200708
[2] Zhu Y, et, al. Synthesis, evaluation, and metabolism of novel [6]-shogaol derivatives as potent Nrf2 activators. Free Radic Biol Med. 2016 Jun;95:243-54. DOI:10.1016/j.freeradbiomed.2016.03.026 |
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