| Identification | Back Directory | [Name]
3,7-dimethyl-8-quinolin-2-ylsulfanylpurine-2,6-dione | [CAS]
878451-87-7 | [Synonyms]
3,7-dimethyl-8-quinolin-2-ylsulfanylpurine-2,6-dione
1H-Purine-2,6-dione, 3,7-dihydro-3,7-dimethyl-8-(2-quinolinylthio)- | [Molecular Formula]
C16H13N5O2S | [MOL File]
878451-87-7.mol | [Molecular Weight]
339.37 |
| Chemical Properties | Back Directory | [density ]
1.54±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 5 mg/mL (14.73 mM);Water : < 0.1 mg/mL (insoluble) | [form ]
Solid | [pka]
9.43±0.70(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Description]
RS-246204 is a small molecule R-spondin-1 substitute. It acts by promoting the initial formation and growth of enteroids in the medium without R-spondin-1. | [Uses]
RS-246204 is a R-spondin-1 substitute compound that is able initiate small intestinal organoids without the use of the R-spondin-1 protein. | [in vivo]
RS-246204 significantly increased BrdU+ cells and body weight in the DSS induced colitis model. These results suggest that RS-246204 activates the R-spondin dependent pathway in Lgr5 stem cells, thereby enhancing proliferation or the anti-apoptotic effect, promoting regeneration of the intestinal epithelium and reducing the disease severity[1]. | [References]
[1] Nam MO, et al. Effects of a small molecule R-spondin-1 substitute RS-246204 on a mouse intestinal organoid culture. Oncotarget. 2017 Dec 26;9(5):6356-6368. DOI:10.18632/oncotarget.23721 |
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PHARMEKS Ltd.
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+7 (495) 702-9648 |
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www.pharmeks.com |
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