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878670-61-2

878670-61-2 Structure

878670-61-2 Structure
IdentificationBack Directory
[Name]

Benzoic acid, 4-[[2-[[5-bromo-4-(4-cyclopropyl-1-naphthalenyl) -4H-1,2,4-triazol -3-yl]thio]acetyl]amino]-3-chloro-
[CAS]

878670-61-2
[Synonyms]

RDEA-806 free acid
RDEA806 free acid,RDEA 806 free acid
4-[[[[5-Bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]acetyl]amino]-3-chlorobenzoic acid
4-[[2-[[5-Bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]acetyl]amino]-3-chlorobenzoic acid
Benzoic acid, 4-[[2-[[5-bromo-4-(4-cyclopropyl-1-naphthalenyl) -4H-1,2,4-triazol -3-yl]thio]acetyl]amino]-3-chloro-
[Molecular Formula]

C24H18BrClN4O3S
[MDL Number]

MFCD19440923
[MOL File]

878670-61-2.mol
[Molecular Weight]

557.847
Chemical PropertiesBack Directory
[density ]

1.69
[pka]

3.87±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

RDEA 806 is an orally active non-nucleoside reverse transcriptase inhibitor (NNRTI) that exhibits potent in vitro inhibitory activity against both wild-type HIV-1 (EC50 = 3.05 nM) and NNRTI-resistant HIV-1[1].
[References]

[1] Moyle G, et al. Phase 2a randomized controlled trial of short-term activity, safety, and pharmacokinetics of a novel nonnucleoside reverse transcriptase inhibitor, RDEA806, in HIV-1-positive, antiretroviral-naive subjects[J]. Antimicrobial agents and chemotherapy, 2010, 54(8): 3170-3178.
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