| Identification | Back Directory | [Name]
15D-PGJ2 | [CAS]
87893-55-8 | [Synonyms]
15d-PGJ?
15D-PGJ2
15-Deoxy-Δ
15-deoxy-&Delta
delta12,14-Pgj 2
15-Deoxy-Δ12,14-PGJ2
12,14-prostaglandin J2
15-DEOXY-DELTA12,14-PGJ2
15-Deoxy-D-12,14-prostaglandin J2
15-Deoxy-delta12,14-prostaglandin
15-DEOXY-DELTA12,14-PROSTAGLANGIN J2
PROSTAGLANDIN J2, 15-DEOXY-DELTA12,14
15-DEOXY-DELTA-12,14-PROSTAGLANDIN J2
15d-PGJ - CAS 87893-55-8 - Calbiochem
11-OXO-PROSTA-5Z,9,12E,14Z-TETRAEN-1-OIC
15-DEOXY-DELTA12,DELTA14-PROSTAGLANDIN J2
15-deoxy-Δ12,14-Prostaglandin J2 solution
15-Deoxy-delta-12-delta-14-prostaglandinej2
11-Oxoprosta-(5Z,9,12E,14E)-tetraen-1-oic acid
15-deoxy-12,14-Prostaglandin J2 MaxSpecStandard
15D-PGJ2 (15-DEOXY-DELTA12,14-PROSTAGLANDIN J2)
15-deoxy-Δ12,14-Prostaglandin J2 Lipid Maps MS Standard
(5Z,12E,14E)-11-OXO-PROSTA-5,9,12,14-TETRAEN-1-OIC ACID
Prosta-5,9,12,14-tetraen-1-oic acid, 11-oxo-, (5Z,12E,14E)-
Prosta-5,9,12,14-tetraen-1-oic acid, 11-oxo-, (5Z,12E,14E)- (9ci)
(Z)-7-[(1S,5E)-5-[(E)-oct-2-enylidene]-4-oxo-1-cyclopent-2-enyl]hept-5-enoic acid | [EINECS(EC#)]
201-185-2 | [Molecular Formula]
C20H28O3 | [MDL Number]
MFCD00065806 | [MOL File]
87893-55-8.mol | [Molecular Weight]
316.43 |
| Hazard Information | Back Directory | [Uses]
15-Deoxy-Δ12,14-prostaglandin J2 has been used:
- to study its effect on lipid accumulation, viability/mitochondrial activity, and amount of vasculature in vascularized adipose tissue model
- as a peroxisome proliferator-activated receptor (PPARγ) agonist to activate intestinal fatty acid binding protein (I-FABP)-PPARγ pathway
- as a supplement in culture medium for induced neural stem/progenitor cells (NSPCs) differentiation
| [Definition]
ChEBI: 15-deoxy-Delta(12,14)-prostaglandin J2 is a prostaglandin J derivative comprising prostaglandin J2 lacking the 15-hydroxy group and having C=C double bonds at the 12- and 14-positions. It has a role as a metabolite, an electrophilic reagent and an insulin-sensitizing drug. It is functionally related to a prostaglandin J2. It is a conjugate acid of a 15-deoxy-Delta(12,14)-prostaglandin J2(1-). | [General Description]
A metabolite of PGD2 that has recently been identified as a natural ligand for PPARγ-dependent adipogenesis in transfected 3T3 cells and for PPARγ response element (PPRE) in CV-1 cells. Competes with thiazolidinediones for PPARγ binding. | [Biological Activity]
Selective PPAR γ agonist that induces adipocyte differentiation in C3H10Y1/2 fibroblasts (EC 50 = 7 μ M). | [Biochem/physiol Actions]
15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) regulates inflammatory response in vivo. 15d-PGJ2 also elicits PPARγ-independent inhibition of nuclear factor (NF)-κB dependent transcription. It acts as an anti-angiogenic factor and triggers endothelial cell apoptosis. |
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