| Identification | Back Directory | [Name]
Benzenesulfonamide, 4-[2-[4-oxo-2-[(phenylmethyl)thio]-3(4H)-quinazolinyl]ethyl]- | [CAS]
879730-44-6 | [Synonyms]
EGFR/HER2/CDK9-IN-1
Benzenesulfonamide, 4-[2-[4-oxo-2-[(phenylmethyl)thio]-3(4H)-quinazolinyl]ethyl]- | [Molecular Formula]
C23H21N3O3S2 | [MOL File]
879730-44-6.mol | [Molecular Weight]
451.56 |
| Hazard Information | Back Directory | [Uses]
EGFR/HER2/CDK9-IN-1 (Compound 4) is a potent inhibitor of EGFR/HER2/CDK9 with IC50s of 90.17, 131.39, and 67.04 nM, respectively. EGFR/HER2/CDK9-IN-1 exhibits remarkable antitumor activity[1]. | [References]
[1] El-Azab AS, et al. Antitumor activity, multitarget mechanisms, and molecular docking studies of quinazoline derivatives based on a benzenesulfonamide scaffold: Cell cycle analysis. Bioorg Chem. 2020;104:104345. DOI:10.1016/j.bioorg.2020.104345 |
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