| Identification | Back Directory | [Name]
2-formyl-1H-Indole-5-carboxylic acid methyl ester | [CAS]
880360-85-0 | [Synonyms]
methyl 2-formyl-1H-indole-5-carboxylate
2-formyl-1H-Indole-5-carboxylic acid methyl ester
1H-Indole-5-carboxylic acid, 2-formyl-, methyl ester | [Molecular Formula]
C11H9NO3 | [MDL Number]
MFCD20528190 | [MOL File]
880360-85-0.mol | [Molecular Weight]
203.19 |
| Chemical Properties | Back Directory | [Boiling point ]
404.4±25.0 °C(Predicted) | [density ]
1.341±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
14.14±0.30(Predicted) | [Appearance]
Light yellow to yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of methyl 2-(hydroxymethyl)-1H-indole-5-carboxylate from methyl 2-(hydroxymethyl)-1H-indole-5-carboxylate: to a stirred solution of methyl 2-(hydroxymethyl)-1H-indole-5-carboxylate (4.7 g, 23.1 mmol) in 70 mL of chloroform was added MnO2 (12.5 g, 115.4 mmol) in batches. After 14 hours of reaction, the mixture was filtered through a diatomaceous earth plug and the filtrate was concentrated under reduced pressure to give methyl 2-formyl-1H-indole-5-carboxylate (4.0 g, 85% yield) as a brown oil. The product could be used in subsequent reactions without further purification. Thin layer chromatography (TLC) Rf = 0.21 (20% EtOAc/hexane). Elemental analysis (C11H11NO3) Calculated value: exact mass 203.06; measured value: 203.06. low resolution mass spectrometry (LRMS) APCI (M-1) m/z 202. | [References]
[1] Patent: US2006/69087, 2006, A1. Location in patent: Page/Page column 14 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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