| Identification | Back Directory | [Name]
Dieckol | [CAS]
88095-77-6 | [Synonyms]
Dieckol
Dibenzo[b,e][1,4]dioxin-1,3,6,8-tetrol, 4-[4-[[6-(3,5-dihydroxyphenoxy)-4,7,9-trihydroxydibenzo[b,e][1,4]dioxin-2-yl]oxy]-3,5-dihydroxyphenoxy]- | [Molecular Formula]
C36H22O18 | [MDL Number]
MFCD20232943 | [MOL File]
88095-77-6.mol | [Molecular Weight]
742.55 |
| Chemical Properties | Back Directory | [Boiling point ]
999.6±65.0 °C(Predicted) | [density ]
1.850±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
Solid | [pka]
7.63±0.20(Predicted) | [color ]
Off-white to light brown |
| Hazard Information | Back Directory | [Chemical Properties]
mp >300℃.Antifibrinolysis
a2-macroglobulin, IC50= 5.0 μg/ml, a2-fibrinolysin, IC50=0.8
ug/ml); antioxidant (DPPH scavenger, IC50-6.2μmol/L, control
Ascorbic acid, IC50=10.3μmol/L）. | [Description]
Constitution.of the brown algae Ecklonia kurome and Eisenia bicyclis. Inhibitor of oz-Macroglobulin,glycation and α-amylase.Cryst. | [Uses]
Dieckol, is a naturally occurring phlorotannin found in some brown algal species. Dieckol has anti-bacterial, anti-cancer, anti-oxidant, anti-aging, anti-diabetic, neuroprotective actions[1]. | [Definition]
ChEBI: Dieckol is a phlorotannin isolated from a brown alga Ecklonia cava which exhibits antioxidant, hepatoprotective and anticoagulant activities. It has a role as a metabolite, a radical scavenger, an EC 3.2.1.20 (alpha-glucosidase) inhibitor, a hepatoprotective agent and an anticoagulant. It is a phlorotannin, an aromatic ether and an oxacycle. It is functionally related to a phloroglucinol. | [in vivo]
Dieckol remarkably inhibited the lipid accumulation in high fat diet induced animal models[1]. | [References]
[1] Durairaj Karthick Rajan, et al. Dieckol: a brown algal phlorotannin with biological potential. Biomed Pharmacother. 2021 Oct;142:111988. DOI:10.1016/j.biopha.2021.111988 |
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