| Identification | Back Directory | [Name]
3-(1H-benzimidazol-2-yl)-1-[3-(dimethylamino)propyl]pyrrolo[3,2-b]quinoxalin-2-amine | [CAS]
881046-01-1 | [Synonyms]
INI43
INI-43
INI 43
INI-43 >=98% (HPLC)
INI-43,NFκB,NFY,AP-1,Inhibitor,inhibit,NFAT,Kpnβ1 cargoes
3-(1H-benzimidazol-2-yl)-1-[3-(dimethylamino)propyl]pyrrolo[3,2-b]quinoxalin-2-amine
1H-Pyrrolo[2,3-b]quinoxaline-1-propanamine, 2-amino-3-(1H-benzimidazol-2-yl)-N,N-dimethyl- | [Molecular Formula]
C22H23N7 | [MDL Number]
MFCD06650809 | [MOL File]
881046-01-1.mol | [Molecular Weight]
385.46 |
| Chemical Properties | Back Directory | [Boiling point ]
684.4±65.0 °C(Predicted) | [density ]
1.37±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 10mg/mL, clear | [form ]
Solid | [pka]
10.80±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
INI-43 is a cell penetrant and potent inhibitor of Kpnb1-mediated nuclear import th at cancer cell death via a G2–M cell cycle arrest followed by apoptosis. INI-43 inhibits the nuclear localization of Kpnb1 as well as th at of its cargo transcription factorsNFYAP-1p65and NFAT. INI-43 exhibit specific cytotoxicity toward cancer cells. INI-43 inhibits tumor growth in cancer xenograft models.''INI-43 is also known as (3-(1H-benzimidazol-2-yl)-1-(3-dimethylaminopropyl)pyrrolo[5,4-b]quinoxalin-2-amine). It has the ability to prevent the development of dermatologically xenografted esophageal and cervical tumor cells. INI-43 can also decrease activator protein 1 (AP-1) transcriptional activityinduced by phorbol-12-myristate-13-acetate (PMA). |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
PHARMEKS Ltd.
|
| Tel: |
+7 (495) 702-9648 |
| Website: |
www.pharmeks.com |
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