| Identification | Back Directory | [Name]
3-bromo-2-nitrobenzaldehyde | [CAS]
882772-99-8 | [Synonyms]
3-bromo-2-nitrobenzaldehyde
Benzaldehyde, 3-bromo-2-nitro- | [Molecular Formula]
C7H4BrNO3 | [MDL Number]
MFCD00462872 | [MOL File]
882772-99-8.mol | [Molecular Weight]
230.02 |
| Chemical Properties | Back Directory | [Melting point ]
75-77 °C | [Boiling point ]
298.7±25.0 °C(Predicted) | [density ]
1.781±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
Pale Yellow |
| Hazard Information | Back Directory | [Uses]
3-Bromo-2-nitrobenzaldehyde is an intermediate in the synthesis of peptidomimetic BACE1 inhibitor. | [Synthesis]
General procedure for the synthesis of 3-bromo-2-nitrobenzaldehyde from 3-bromo-2-nitrobenzenemethanol: 14.0 g of 3-bromo-2-nitrobenzenemethanol and 150 mL of 1,2-dichloroethane were added to a three-necked flask, followed by 42.0 g of manganese dioxide. The mixture was heated to reflux. After completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the filtrate was concentrated. Purification by column chromatography separation resulted in 9.4 g (67.7% yield) of 3-bromo-2-nitrobenzaldehyde. | [References]
[1] Patent: CN103880683, 2018, B. Location in patent: Paragraph 0024; 0033-0034; 0045 |
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