| Identification | Back Directory | [Name]
2-PYRAZIN-2-YL-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHANONE
| [CAS]
88283-34-5 | [Synonyms]
11β-HSD1-IN-9
2-(Pyrazin-2-yl)-[4-(trifluoromethyl)phenyl]ethan-1-one
Ethanone, 2-(2-pyrazinyl)-1-[4-(trifluoromethyl)phenyl]-
2-(2-pyrazinyl)-2-[4-(trifluoromethyl)phenyl]acetaldehyde
2-(Pyrazin-2-yl)-[4-(trifluoromethyl)phenyl]ethan-1-one 95+% | [Molecular Formula]
C13H9F3N2O | [MDL Number]
MFCD04037908 | [MOL File]
88283-34-5.mol | [Molecular Weight]
266.22 |
| Hazard Information | Back Directory | [Uses]
11β-HSD1-IN-9 (compound c4a) is a potent 11β-HSD1 inhibitor with IC50 values of 0.48 and 1.3 μM for human and murine 11β-HSD1, respectively. 11β-HSD1-IN-9 competitively interacts with rat 11β-HSD1. 11β-HSD1-IN-19 can be used in studies of obesity, hyperglycemia and cognitive impairment[1]. | [References]
[1] Naredo-Gonzalez G, et al. Non-invasive in vivo assessment of 11β-hydroxysteroid dehydrogenase type 1 activity by 19F-Magnetic Resonance Spectroscopy. Sci Rep. 2022 Sep 29;12(1):16268. DOI:10.1038/s41598-022-18740-5 |
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