| Identification | Back Directory | [Name]
Phosphoric acid, mono(2-aminoethyl) mono(2,3-dihydroxypropyl) ester, monosodium salt (9CI) | [CAS]
883288-78-6 | [Synonyms]
LUM88786
Phosphoric acid, mono(2-aminoethyl) mono(2,3-dihydroxypropyl) ester, monosodium salt (9CI) | [Molecular Formula]
C5H15NNaO6P | [MOL File]
883288-78-6.mol | [Molecular Weight]
239.14 |
| Hazard Information | Back Directory | [Uses]
Glycerophosphorylethanolamine (GroPEtn) sodium is an active phosphodiester metabolite of Phosphatidylethanolamine (HY-W250118). Glycerophosphorylethanolamine sodium promotes the aggregation of amyloid β-protein (Aβ (1-40)) in vitro. Glycerophosphorylethanolamine sodium can be used in the field of neurodegenerative diseases, such as Alzheimer’s disease research[1]. | [Biological Activity]
Glycerophosphorylethanolamine is an active phosphodiester metabolite of phosphatidylethanolamine.1,2 It promotes aggregation of amyloid-β (1-40) (Aβ40) in vitro, and levels of glycerophosphorylethanolamine are elevated in postmortem brains isolated from patients with Alzheimer’s disease. | [References]
1.Klunk, W.E., Xu, C.J., McClure, R.J., et al.Aggregation of β-amyloid peptide is promoted by membrane phospholipid metabolites elevated in Alzheimer’s disease brainJ. Neurochem.69(1)266-272(1997)
2.Blusztajn, J.K., Lopez Gonzalez-Coviella, I., Logue, M., et al.Levels of phospholipid catabolic intermediates, glycerophosphocholine and glycerophosphoethanolamine, are elevated in brains of Alzheimer’s disease but not of Down’s syndrome patientsBrain Res.536(1-2)240-244(1990)
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