| Identification | Back Directory | [Name]
2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER | [CAS]
884494-84-2 | [Synonyms]
Methyl 2-Fluoro-4-iodonicotinate
2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER
Methyl 2-Fluoro-4-iodopyridin-3-ylcarbanate
Methyl 2-fluoro-4-iodopyridine-3-carboxylate
2-Fluoro-4-iodo-3-pyridinecarboxylic acid methyl ester
3-PYRIDINECARBOXYLIC ACID, 2-FLUORO-4-IODO-,METHYL ESTER
Methyl 2-fluoro-4-iodopyridine-3-carboxylate, 2-Fluoro-4-iodo-3-(methoxycarbonyl)pyridine | [Molecular Formula]
C7H5FINO2 | [MDL Number]
MFCD04972401 | [MOL File]
884494-84-2.mol | [Molecular Weight]
281.02 |
| Chemical Properties | Back Directory | [Boiling point ]
287℃ | [density ]
1.913 | [Fp ]
127℃ | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
-3.86±0.18(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
GENERAL STEPS: 2-Fluoro-4-iodonicotinic acid (5.13 g) was dissolved in a solvent mixture of ether (25 mL) and methanol (25 mL) under nitrogen protection. To this solution was slowly added a 10% hexane solution of trimethylsilylated diazomethane (32.9 g). The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the reaction solution was concentrated and the resulting residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate gradient) to afford methyl 2-fluoro-4-iodonicotinate (5.3 g). The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 3.94 (3H, s), 7.98 (1H, dd, J = 5.3, 1.1 Hz), 8.07 (1H, dd, J = 5.3, 0.8 Hz). | [References]
[1] Patent: EP2921480, 2015, A1. Location in patent: Paragraph 0391; 0392
[2] Patent: WO2016/95204, 2016, A1. Location in patent: Page/Page column 62; 63 |
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