| Identification | Back Directory | [Name]
Tert-butyl 2,6-diazaspiro[3.4]octane-2-carboxylate | [CAS]
885270-84-8 | [Synonyms]
tert-Butyl 2,6-diazaspiro...
2-Boc-2,6-diaza-spiro[3.4]octane
2,6-Diazaspiro[3.4]octane, N2-BOC protected
tert-Butyl 2,7-diazaspiro[3.4]octane-2-carboxylate
2,6-Diaza-spiro[3.4]octane-2-carboxylic acid tert-butyl
1,1-Dimethylethyl 2,6-diazaspiro[3.4]octane-2-carboxylate
2,6-Diazaspiro[3.4]octan-2-carboxylic acid tert-butyl ester
Tert-butyl 2,6-diazaspiro[3.4]octane-2-carboxylate.hemioxalate
2,6-Diazaspiro[3.4]octane-2-carboxylicacid, 1,1-dimethylethy...
2,6-Diazaspiro[3.4]octane-2-carboxylic acid, 1,1-diMethylethyl ester
Tert-butyl 2,6-diazaspiro[3.4]octanTert-butyl 2,6-diazaspiro[3.4]octane-2-carboxylatee-2-carboxylate | [Molecular Formula]
C11H20N2O2 | [MDL Number]
MFCD08234737 | [MOL File]
885270-84-8.mol | [Molecular Weight]
212.29 |
| Chemical Properties | Back Directory | [Boiling point ]
301.3±35.0 °C(Predicted) | [density ]
1.10±0.1 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [form ]
solid | [pka]
10.65±0.20(Predicted) | [color ]
Off-white | [InChI]
InChI=1S/C11H20N2O2/c1-10(2,3)15-9(14)13-7-11(8-13)4-5-12-6-11/h12H,4-8H2,1-3H3 | [InChIKey]
UJIOQJJFPYXAEM-UHFFFAOYSA-N | [SMILES]
C1C2(CCNC2)CN1C(OC(C)(C)C)=O |
| Hazard Information | Back Directory | [Uses]
tert-Butyl 2,6-diazaspiro[3.4]octane-2-carboxylate can be used to synthesize ketohexokinase (KHK) inhibitors that have potential medical uses for treating diabetes and obesity.??tert-Butyl 2,6-diazaspiro[3.4]octane-2-carboxylate is also a useful reagent for the synthesis of dihydroisoindolecarboxamide derivatives as??Nicotinamide Phosphoribosyltransferase (NAMPT) and??Rho-associated protein kinase (ROCK)??inhibitors. | [Pharmaceutical Applications]
2,6-diazaspiro[3.4]octane is the main structure of Tert-butyl 2,6-diazaspiro[3.4]octane-2-carboxylate. The fully saturated, high-Fsp3 2,6-diazaspiro[3.4]octane core is an emerging privileged structure, taking into account its recent frequent appearance in compounds possessing diverse biological activities. Notable recently reported examples include a hepatitis B capsid protein inhibitor, a menin-MLL1 interaction inhibitor for the treatment of cancer, a MAP and PI3K signaling modulator, a selective dopamine D3 receptor antagonist, and VDAC1 inhibitors for the treatment of diabetes[1]. | [References]
[1] Lukin, A.; Komarova, K.; Vinogradova, L.; Dogonadze, M.; Vinogradova, T.; Yablonsky, P.; Kazantsev, A.; Krasavin, M. Periphery Exploration around 2,6-Diazaspiro[3.4]octane Core Identifies a Potent Nitrofuran Antitubercular Lead. Molecules 2023, 28, 2529. DOI:10.3390/molecules28062529
|
|
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 18918157536; |
| Website: |
http://www.energy-chemical.com |
|