| Identification | Back Directory | [Name]
3-IODO-1H-INDAZOLE-5-CARBOXYLIC ACID METHYL ESTER | [CAS]
885271-25-0 | [Synonyms]
Methyl 3-iodoindazole-5-c...
Methyl 3-iodoindazole-5-carboxylate
3-Iodo-5-(methoxycarbonyl)-1H-indazole
Methyl 3-iodo-1H-indazole-5-carboxylate
Methyl 3-iodo-1H-indazole-7-carboxylate
3-IODO-5-INDAZOLECARBOXYLIC ACID METHYL ESTER
1H-Indazole-5-carboxylicacid,3-iodo-,Methylester
3-IODO-1H-INDAZOLE-5-CARBOXYLIC ACID METHYL ESTER | [Molecular Formula]
C9H7IN2O2 | [MDL Number]
MFCD06739144 | [MOL File]
885271-25-0.mol | [Molecular Weight]
302.07 |
| Chemical Properties | Back Directory | [Boiling point ]
421.4±25.0 °C(Predicted) | [density ]
1.948 | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
10.85±0.40(Predicted) | [Appearance]
Light yellow to yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
GENERAL METHOD: To a cooled DMF solution, methyl 1H-indazole-5-carboxylate (1.0 eq.), K2CO3 or KOH (ca. 3 eq.), and I2 (2-4 eq.) were sequentially added at 0 °C. The reaction mixture was stirred under cooling conditions or at room temperature for several hours. Upon completion of the reaction, the reaction is quenched with an excess of 10% aqueous NaHSO3, followed by dilution with H2O. In most cases, the precipitate is collected by filtration and washed with H2O to give methyl 3-iodo-5-indazolecarboxylate of the desired purity. | [References]
[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 17, p. 4968 - 4997
[2] Patent: WO2017/136395, 2017, A1. Location in patent: Page/Page column 197
[3] Patent: WO2006/86255, 2006, A2. Location in patent: Page/Page column 85; 86
[4] Patent: WO2017/35349, 2017, A1. Location in patent: Paragraph 0539 |
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