| Identification | Back Directory | [Name]
6-BROMO-1H-INDAZOLE-3-CARBALDEHYDE | [CAS]
885271-72-7 | [Synonyms]
Bromoindazolecarboxaldehyde
6-BROMO-INDAZOLE-3-CARBOXALDEHYDE
6-BROMO-1H-INDAZOLE-3-CARBALDEHYDE
6-BROMO-1H-INDAZOLE-3-CARBOXALDEHYDE
1H-Indazole-3-carboxaldehyde,6-broMo-
6-Bromo-1H-indazole-3-carboxyaldehyde
6-Bromo-1H-indazole-3-carbaldehyde 97%
1-(6-bromo-1H-indazol-3-yl)-N,N-dimethylmethanamine
6-BROMO-1H-INDAZOLE-3-CARBALDEHYDE ISO 9001：2015 REACH | [Molecular Formula]
C8H5BrN2O | [MDL Number]
MFCD06738286 | [MOL File]
885271-72-7.mol | [Molecular Weight]
225.04 |
| Chemical Properties | Back Directory | [Boiling point ]
414.1±25.0 °C(Predicted) | [density ]
1.830±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [form ]
solid | [pka]
10.82±0.40(Predicted) | [color ]
Brown |
| Hazard Information | Back Directory | [Uses]
6-Bromo-1H-indazole-3-carbaldehyde is an indazole compound, mostly used in chemical manufacturing or pharmaceutical intermediate components. | [Synthesis]
6-Bromo-1H-indazole-3-carbaldehyde is prepared by the reaction of 6-Bromoindole and acetone. The specific synthesis steps are as follows:
To 70g is added in an aqueous solution of sodium nitrite of 20g 6-bromoindole acetone: water (200 ml: 200 ml) solution; room temperature, in to the system by adding 2N HCl solution to pH to 2.5 the left and right; 20 min the rear, with a red brown gas desorbing, slabs system has; 10 min later, TLC detection material disappears, cessation of the reaction, adding to system 1.0L ethyl acetate (EA), two-phase separation, the organic phase with saturated sodium bicarbonate (500 ml * 2) washing, drying organic anhydrous magnesium sulfate, concentrated to obtain 22g compound 2, as a black solid.
 | [References]
[1] Patent: WO2016/57834, 2016, A1. Location in patent: Paragraph 000263
[2] Patent: CN104098513, 2016, B. Location in patent: Paragraph 0023; 0024; 0029
[3] Patent: WO2017/79205, 2017, A1. Location in patent: Page/Page column 35 |
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