| Identification | Back Directory | [Name]
Cyclooctyne-O-PFP ester | [CAS]
886209-60-5 | [Synonyms]
Cyclooctyne-O-PFP ester
perfluorophenyl2-(cyclooct-2-ynyloxy)acetate
Acetic acid, 2-(2-cyclooctyn-1-yloxy)-, 2,3,4,5,6-pentafluorophenyl ester | [Molecular Formula]
C16H13F5O3 | [MDL Number]
MFCD28899000 | [MOL File]
886209-60-5.mol | [Molecular Weight]
348.26 |
| Hazard Information | Back Directory | [Uses]
Cyclooctyne-O-PFP ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Cyclooctyne-O-PFP ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
Cleavable Linker | [References]
[1] Sun, Ying, et al. Anti-PSMA Antibodies Conjugated to Nuclear Receptor Ligand Polypeptides. 20150152187A1. |
|
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
|