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886209-60-5

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886209-60-5 Structure

886209-60-5 Structure
IdentificationBack Directory
[Name]

Cyclooctyne-O-PFP ester
[CAS]

886209-60-5
[Synonyms]

Cyclooctyne-O-PFP ester
perfluorophenyl2-(cyclooct-2-ynyloxy)acetate
Acetic acid, 2-(2-cyclooctyn-1-yloxy)-, 2,3,4,5,6-pentafluorophenyl ester
[Molecular Formula]

C16H13F5O3
[MDL Number]

MFCD28899000
[MOL File]

886209-60-5.mol
[Molecular Weight]

348.26
Chemical PropertiesBack Directory
[Boiling point ]

384.9±42.0 °C(Predicted)
[density ]

1.38±0.1 g/cm3(Predicted)
[form ]

Oil
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Cyclooctyne-O-PFP ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Cyclooctyne-O-PFP ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
[IC 50]

Cleavable Linker
[References]

[1] Sun, Ying, et al. Anti-PSMA Antibodies Conjugated to Nuclear Receptor Ligand Polypeptides. 20150152187A1.
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