| Identification | Back Directory | [Name]
3-Trifluoromethyl-piperazine-1-carboxylic acid tert-butyl ester | [CAS]
886779-69-7 | [Synonyms]
1-Boc-3-(trifluoromethyl)piperazine
tert-butyl 3-(trifluoromethyl)piperazine-1-carboxylate
1-Piperazinecarboxylic acid, 3-(trifluoromethyl)-, 1,1-dimethylethyl ester | [Molecular Formula]
C10H17F3N2O2 | [MOL File]
886779-69-7.mol | [Molecular Weight]
254.25 |
| Chemical Properties | Back Directory | [Boiling point ]
263.4±35.0 °C(Predicted) | [density ]
1.189±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
5.95±0.40(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
To a solution of 2-(trifluoromethyl)piperazine (135 mg, 0.876 mmol) in dichloromethane (6 mL) was added di-tert-butyl dicarbonate (0.224 mL, 0.963 mmol) and the reaction mixture was stirred for 3 hours at room temperature. After completion of the reaction, the mixture was concentrated and the residue was purified by silica gel column chromatography (eluent: 0-100% hexane solution of ethyl acetate) to afford 1-Boc-3-trifluoromethylpiperazine (200 mg, 0.787 mmol, 90% yield) as a light yellow solid. Mass spectrometry (ES+) analysis: the theoretical value of C10H17F3N2O2 was 254 and the measured value was 155 [M+H]+ - Boc group. | [References]
[1] Patent: WO2018/136887, 2018, A1. Location in patent: Page/Page column 122
[2] Patent: WO2014/175621, 2014, A1. Location in patent: Paragraph 662; 663; 664 |
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| Company Name: |
Struchem Co., Ltd.
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| Tel: |
0512-63009836 18994340901 |
| Website: |
www.beidapharma.com |
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