| Identification | Back Directory | [Name]
(3S)-3-(Methylamino)-4-(phenylamino)-1-butanol | [CAS]
88733-39-5 | [Synonyms]
(S)-4-Anilino-3-methylamino-1-butanol
(S)-3-(Methylamino)-4-(phenylamino)-1-butanol
(3S)-3-(Methylamino)-4-(phenylamino)-1-butanol
1-Butanol, 3-(methylamino)-4-(phenylamino)-, (3S)- | [Molecular Formula]
C11H18N2O | [MDL Number]
MFCD22648302 | [MOL File]
88733-39-5.mol | [Molecular Weight]
194.27 |
| Chemical Properties | Back Directory | [alpha ]
[α]23D -13.7° (c 1.0, CHCl3). | [Boiling point ]
364.2±37.0 °C(Predicted) | [density ]
1.069 | [solubility ]
sol THF | [pka]
14.93±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
(3S)-3-(Methylamino)-4-(phenylamino)-1-butanol can be used to modify LiAlH4 with tridentate chiral ligands for the enantioselective reduction of alkylphenyl ketones 2 and α,β-unsaturated ketones. | [Preparation]
β-benzyl N-benzyloxycarbonylaspartate4 is treated with ethyl chloroformate, Nmethymorpholine, and aniline. Subsequent reduction of the corresponding anilide with LiAlH4 gives the title reagent in overall 80% yield. |
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