| Identification | Back Directory | [Name]
N-[5-[(4-Fluorophenyl)methyl]-2-thiazolyl]-4-(1H-tetrazol-1-yl)benzamide | [CAS]
887349-03-3 | [Synonyms]
Anticancer agent 110
N-[5-[(4-Fluorophenyl)methyl]-2-thiazolyl]-4-(1H-tetrazol-1-yl)benzamide | [Molecular Formula]
C18H13FN6OS | [MOL File]
887349-03-3.mol | [Molecular Weight]
380.4 |
| Hazard Information | Back Directory | [Uses]
Anticancer agent 110 is an anticancer agent with in vitro anticancer activity and excellent anti-leukemia potency. Anticancer agent 110 is highly cytotoxic to K-562 lineage chronic myelogenous leukemia cells at nanomolar concentrations. Anticancer agent 110 causes DNA damage and leads to apoptosis[1]. | [References]
[1] Pokhodylo N, et al. Bioisosteric replacement of 1H-1,2,3-triazole with 1H-tetrazole ring enhances anti-leukemic activity of (5-benzylthiazol-2-yl)benzamides. Eur J Med Chem. 2023 Mar 15;250:115126. DOI:10.1016/j.ejmech.2023.115126 |
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