| Identification | Back Directory | [Name]
MK-0674 | [CAS]
887781-62-6 | [Synonyms]
MK-0674
MK0674,MK 0674
(2S)-N-(1-cyanocyclopropyl)-2-[[(1S)-1-[4-[4-[(1R)-2,2-difluoro-1-hydroxyethyl]phenyl]phenyl]-2,2,2-trifluoroethyl]amino]-4-fluoro-4-methylpentanamide
Pentanamide, N-(1-cyanocyclopropyl)-2-[[(1S)-1-[4'-[(1R)-2,2-difluoro-1-hydroxyethyl][1,1'-biphenyl]-4-yl]-2,2,2-trifluoroethyl]amino]-4-fluoro-4-methyl-, (2S)- | [Molecular Formula]
C26H27F6N3O2 | [MDL Number]
MFCD16038926 | [MOL File]
887781-62-6.mol | [Molecular Weight]
527.5 |
| Hazard Information | Back Directory | [Uses]
MK-0674 is a potent, orally bioavailable and selective cathepsin K inhibitor, with an IC50 of 0.4 nM, shows 1156, 1465, 11857 and 243 fold selectivity over Cat B, Cat F, Cat L and Cat S[1]. | [References]
[1] Isabel E, et al. The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor. Bioorg Med Chem Lett. 2010 Feb 1;20(3):887-92. DOI:10.1016/j.bmcl.2009.12.083 |
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| Company Name: |
cjbscvictory
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| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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