| Identification | Back Directory | [Name]
BZ-PHE-VAL-ARG-AMC | [CAS]
88899-22-3 | [Synonyms]
BENZOYL-FVR-AMC
BZ-PHE-VAL-ARG-AMC
BZ-PHE-VAL-ARG-AMC HCL
BENZOYL-PHE-VAL-ARG-AMC
THROMBIN SUBSTRATE III, FLUOROGENIC
Bz-Phe-Val-Arg-AMC hydrochloride salt
N-BENZOYL-PHE-VAL-ARG 7-AMIDO-4- &
BENZOYL-PHE-VAL-ARG-AMC: BENZOYL-FVR-AMC
N-BENZOYL-PHE-VAL-ARG 7-AMIDO-4-METHYLCOUMARIN
BENZOYL-PHE-VAL-ARG-7-AMIDO-4-METHYLCOUMARIN HCL
N-BENZOYL-L-PHE-VAL-ARG-7-AMIDO-4-METHYL-COUMARIN HCL
THROMBIN SUBSTRATE III, FLUOROGENIC ; BENZOYL-PHE-VAL-ARG-AMC
N-Benzoyl-L-phenylalanyl-L-valyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-argininamide
L-Argininamide, N-benzoyl-L-phenylalanyl-L-valyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)- | [Molecular Formula]
C37H43N7O6 | [MDL Number]
MFCD00057304 | [MOL File]
88899-22-3.mol | [Molecular Weight]
681.78 |
| Hazard Information | Back Directory | [Uses]
Bz-FVR-AMC is a fluorogenic substrate for procathepsin with a kcat/Km value of 1070 mM-1s-1. The high concentration of BZ-FVR-AMC inhibits the substrate[1][2]. | [References]
[1] Vasiljeva O, et al. Recombinant human procathepsin S is capable of autocatalytic processing at neutral pH in the presence of glycosaminoglycans. FEBS Lett. 2005 Feb 14;579(5):1285-90. DOI:10.1016/j.febslet.2004.12.093
[2] Vasiljeva O, et al. Recombinant human cathepsin H lacking the mini chain is an endopeptidase. Biochemistry. 2003 Nov 25;42(46):13522-8. DOI:10.1021/bi035355k |
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