| Identification | Back Directory | [Name]
2-Pyridinecarboxylic acid, 5,6-dichloro- | [CAS]
88912-24-7 | [Synonyms]
5,6-dichloropicolinic acid
2,3Dichloro6carboxypyridine
5,6-Dichloropicolinic acid 98%
5,6-Dichloro-2-pyridinecarboxylicacid
5,6-Dichloropyridine-2-carboxylic acid
2-Pyridinecarboxylic acid, 5,6-dichloro-
5,6-Dichloropyridine-2-carboxylicacid,98%
5,6-Dichloro-2-pyridinecarboxylic acid
5,6dichloropicolinic acid | [EINECS(EC#)]
-0 | [Molecular Formula]
C6H3Cl2NO2 | [MDL Number]
MFCD13185546 | [MOL File]
88912-24-7.mol | [Molecular Weight]
192 |
| Chemical Properties | Back Directory | [Boiling point ]
342.1±37.0 °C(Predicted) | [density ]
1.612±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [form ]
Solid | [pka]
3.04±0.10(Predicted) | [Appearance]
White to off-white Solid | [InChI]
InChI=1S/C6H3Cl2NO2/c7-3-1-2-4(6(10)11)9-5(3)8/h1-2H,(H,10,11) | [InChIKey]
QOJNAEPFSUYAFL-UHFFFAOYSA-N | [SMILES]
C1(C(O)=O)=NC(Cl)=C(Cl)C=C1 |
| Hazard Information | Back Directory | [Uses]
2-Pyridinecarboxylic acid, 5,6-dichlorois known for its role in the
synthesis of pharmaceuticals and agrochemicals, as well as its utility
as a building block in organic synthesis and a reagent in various
chemical reactions. | [Synthesis]
5-Chloro-1-yloxy-pyridine-2-carboxylic acid (CAS: 1415898-80-4, 1.2 g, 7 mmol) was used as a raw material and was slowly added to phosphorus trichloride (POCl3, 10 g) at 0 °C. The reaction mixture was warmed up to 95 °C and maintained at this temperature for 1 hour. After completion of the reaction, the mixture was concentrated to dryness under reduced pressure. The residue was dissolved in water (15 mL) and extracted with ethyl acetate (2 × 15 mL). The organic phases were combined and washed sequentially with water (2 × 30 mL) and saturated saline (30 mL). The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford 5,6-dichloro-2-pyridinecarboxylic acid (1 g, 75% yield) as a yellow solid. The product was confirmed by mass spectrometry (EI), m/e = 191.9 [M + H]+. | [References]
[1] Patent: US2012/316147, 2012, A1. Location in patent: Page/Page column 66
[2] Patent: WO2012/168350, 2012, A1. Location in patent: Page/Page column 140 |
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