| Identification | Back Directory | [Name]
Benzoic acid, 5-[[4-[(2-furanylcarbonyl)amino]benzoyl]amino]-2-hydroxy- | [CAS]
891002-11-2 | [Synonyms]
SIRT6-IN-5
SIRT6-IN-2
SIRT6 inhibitor5
SIRT6 inhibitor-5
SIRT6 inhibitor 5
SIRT6IN5,SIRT-6-IN-5
5-[4-(furan-2-amido)benzamido]-2-hydroxybenzoic acid
Benzoic acid, 5-[[4-[(2-furanylcarbonyl)amino]benzoyl]amino]-2-hydroxy- | [Molecular Formula]
C19H14N2O6 | [MDL Number]
MFCD07114223 | [MOL File]
891002-11-2.mol | [Molecular Weight]
366.32 |
| Chemical Properties | Back Directory | [Boiling point ]
461.6±45.0 °C(Predicted) | [density ]
1.520±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
2.96±0.10(Predicted) | [color ]
Off-white to gray |
| Hazard Information | Back Directory | [Uses]
SIRT6-IN-2 (Compound 5) is a selective SIRT6 inhibitor (IC50: 34 μM). SIRT6-IN-2 increases acetylation of H3K9 and increases glucose uptake in cultured cells. SIRT6-IN-2 also reduces T cell proliferation. SIRT6-IN-2 has immunosuppressive and chemosensitizing effects[1]. | [References]
[1] Damonte P, et al. SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects. Bioorg Med Chem. 2017 Oct 15;25(20):5849-5858. DOI:10.1016/j.bmc.2017.09.023 |
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