| Hazard Information | Back Directory | [Uses]
AKR1C3-IN-12 (compound 2j) is an aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC50 of 27 nM. AKR1C3-IN-12 enhances the efficacy of Gemcitabine and Cisplatin in bladder cancer[1]. | [References]
[1] Rin Himura, et al. Inhibition of aldo-keto reductase 1C3 overcomes gemcitabine/cisplatin resistance in bladder cancer. Chem Biol Interact. 2024 Jan 25:388:110840. DOI:10.1016/j.cbi.2023.110840 |
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