ChemicalBook--->CAS DataBase List--->891494-63-6

891494-63-6

891494-63-6 Structure

891494-63-6 Structure
IdentificationBack Directory
[Name]

SCH900776
[CAS]

891494-63-6
[Synonyms]

SCH900776(R)
SCH 900776, >=98%
SCH900776 USP/EP/BP
MK-8776 (SCH 900776)
SCH 900776 (MK-8776)
MK-8776 (SCH900776)(S)
SCH-900776; SCH 900776; MK-8776.
6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(3R)-3-piperidinylpyrazolo[1,5-a]pyrimidin-7-amine
(R)-6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine
6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-((R)-piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine
Pyrazolo[1,5-a]pyrimidin-7-amine, 6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(3R)-3-piperidinyl-
[Molecular Formula]

C15H18BrN7
[MDL Number]

MFCD20922873
[MOL File]

891494-63-6.mol
[Molecular Weight]

376.254
Chemical PropertiesBack Directory
[density ]

1.80
[solubility ]

insoluble in H2O; insoluble in EtOH; ≥18.8 mg/mL in DMSO
[pka]

8.88±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

This compound acts as a novel Chk1 inhibitor acting as an anticancer agent.
[Biological Activity]

sch 900776 is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (chk1), chk2 and cdk3 with ic50 value of 3 nm, 1.5μm and 0.16 μm, respectively.chk is s serine/threonine kinase that senses signal of dna damage and stalls dna replication, and also plays an essential role in the maintenance of replication fork viability during exposure to dna antimetabolites.in balb/c mice, administration of sch 900776 at a dosage of 8mg/kg after gemcitabine treatment can sufficiently induce enhanced tumor pharmacodynamic and regression responses as compared to gemcitabine or sch 900776 alone 1.
[in vitro]

sch 900776 blocked accumulation of the chk1 ps296 autophosphorylation in a dose-dependent manner. treatment of proliferating ws1 cells with sch 900776 was found to be associated with rapid, dose-dependent accumulation of chk1 ps345, indicating that cycling populations of normal cells induce chk1 ps345 in response to the inhibition of sch 900776 as part of a futile cycle 1.
[References]

1. guzi tj, paruch k, dwyer mp, et al. targeting the replication checkpoint using sch 900776, a potent and functionally selective chk1 inhibitor identified via high content screening. molecular cancer therapeutics. 2011;10(4):591-602.
Spectrum DetailBack Directory
[Spectrum Detail]

SCH900776(891494-63-6)1HNMR
891494-63-6 suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: 21-51619050
Website: http://www.atkchemical.com
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258
Website: www.coreychem.com/index.html
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250 , +86-15129568250
Website: https://www.dideu.com
Company Name: InvivoChem
Tel: +1-708-3101919
Website: https://www.invivochem.com/
Company Name: Nantong HI-FUTURE Biology Co., Ltd.
Tel: +undefined18051384581 , +undefined18051384581
Website: https://www.chemhifuture.com/
Company Name: ShenZhen Trendseen Biological Technology Co.,Ltd.
Tel: 13417589054 , 13417589054
Website: www.chemicalbook.com/ShowSupplierProductsList1962465/0.htm
Company Name: Amadis Chemical Company Limited
Tel: 571-89925085
Website: www.amadischem.com
Company Name: Shanghai Boyle Chemical Co., Ltd.  
Tel:
Website: www.boylechem.com
Company Name: J & K SCIENTIFIC LTD.  
Tel: 010-82848833 400-666-7788
Website: http://www.jkchemical.com
Company Name: Jia Xing Isenchem Co.,Ltd  
Tel: 0573-85285100 18627885956
Website: https://www.chemicalbook.com/ShowSupplierProductsList14265/0.htm
Company Name: Jinan Trio PharmaTech Co., Ltd.  
Tel: +86 (531) 88811783
Website: www.trio-pharmatech.com
Company Name: Dalian Meilun Biotech Co., Ltd.  
Tel: 0411-62910999 13889544652
Website: www.meilune.com/
Company Name: NCE Biomedical Co.,Ltd.  
Tel: 4000-027-021 |24 hour enquiry :+86-13986109188 |English:+86-15623472865 |Japanese:+81-08033611988
Website: www.chemicalbook.com/ShowSupplierProductsList15748/0.htm
Company Name: Shanghai T&W Pharmaceutical Co., Ltd.  
Tel: +86 21 61551611
Website: www.trustwe.com
Company Name: Haoyuan Chemexpress Co., Ltd.  
Tel: 021-58950125
Website: gb.chemexpress.com.cn
Company Name: MedChemexpress LLC  
Tel: 021-58955995
Website: www.medchemexpress.cn
Company Name: Guangzhou Isun Pharmaceutical Co., Ltd  
Tel: 020-39119399 18927568969
Website: http://www.isunpharm.com
Company Name: AdooQ BioScience, LLC   
Tel: +1 (866) 930-6790
Website: www.adooq.com
Tags:891494-63-6 Related Product Information
1226781-44-7 930-36-9 763113-22-0 1028486-01-2 953778-58-0 902240-86-2 1032350-13-2 935273-79-3 1207253-08-4 328232-95-7 1206524-85-7 917879-39-1 115104-28-4 847818-55-7 33641-15-5 955365-80-7 860352-01-8 1232410-49-9