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89196-95-2

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89196-95-2 Structure

89196-95-2 Structure
IdentificationBack Directory
[Name]

2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE
[CAS]

89196-95-2
[Synonyms]

2-BFI HCL
2-BFI HYDROCHLORIDE
2-BFI hydrochlorid (2 BFI hydrochloride
2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE
2-(Benzofuran-2-yl)-2-imidazoline Hydrochloride
[Molecular Formula]

C11H11ClN2O
[MDL Number]

MFCD00672666
[MOL File]

89196-95-2.mol
[Molecular Weight]

222.67
Chemical PropertiesBack Directory
[storage temp. ]

Desiccate at RT
[solubility ]

DMSO: 20mg/mL, clear
[form ]

White powder.
[color ]

White to off-white
[Water Solubility ]

Soluble to 100 mM in water
[InChI]

1S/C11H10N2O.ClH/c1-2-4-9-8(3-1)7-10(14-9)11-12-5-6-13-11;/h1-4,7H,5-6H2,(H,12,13);1H
[InChIKey]

RFNFFVDVGWOSNZ-UHFFFAOYSA-N
[SMILES]

[H]Cl.C12=CC=CC=C1OC(C3=NCCN3)=C2
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501
[WGK Germany ]

WGK 3
[Storage Class]

11 - Combustible Solids
[Hazard Classifications]

Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
Hazard InformationBack Directory
[Uses]

2-(Benzofuran-2-yl)-2-imidazoline Hydrochloride is a I2 receptor agonists that induces hypothermic effect in rats.
[Biological Activity]

High affinity I 2 ligand (K i = 9.8 nM). Putative I 2 agonist; potentiates morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.
[in vivo]

RX 801077 hydrochloride (5, 10, 20 mg/kg; i.p.; twice daily for 3 days) inhibits NLRP3 inflammasome-induced inflammation and necroptosis in a rat model of traumatic brain injury[2].

Animal Model:280-300 g, Male adult Sprague-Dawley rats (TBI model)[2]
Dosage:5, 10, 20 mg/kg
Administration:I.p.; twice daily for 3 days
Result:Attenuated neurological deficits, brain edema, BBB permeability and cortical tissue loss in a rat model of TBI, reduced microglial activation, neutrophil infiltration, and proinflammatory cytokine IL-1β secretion, reduced the expression of RIP1 and RIP3 in neurons in the pericontusional cortex.
[storage]

Desiccate at RT
Spectrum DetailBack Directory
[Spectrum Detail]

2-(2-BENZOFURANYL)-2-IMIDAZOLINE HYDROCHLORIDE(89196-95-2)1HNMR
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