| Identification | Back Directory | [Name]
2-(CHLOROMETHYL)-4-(4-NITROPHENYL)-1,3-THIAZOLE | [CAS]
89250-26-0 | [Synonyms]
Astragalus Polysacharin
Astragalus pulysacharide
2-(Chloromethyl)-4-(4-nitrophenyl)thiazole
thiazole, 2-(chloroMethyl)-4-(4-nitrophenyl)-
2-(CHLOROMETHYL)-4-(4-NITROPHENYL)-1,3-THIAZOLE | [EINECS(EC#)]
2017-001-1 | [Molecular Formula]
C10H7ClN2O2S | [MDL Number]
MFCD02180551 | [MOL File]
89250-26-0.mol | [Molecular Weight]
254.69 |
| Chemical Properties | Back Directory | [Melting point ]
154.5 °C | [Boiling point ]
406.2±30.0 °C(Predicted) | [density ]
1.439 | [storage temp. ]
Sealed in dry,2-8°C | [pka]
0.32±0.10(Predicted) | [InChI]
InChI=1S/C10H7ClN2O2S/c11-5-10-12-9(6-16-10)7-1-3-8(4-2-7)13(14)15/h1-4,6H,5H2 | [InChIKey]
LEBRGKZHLICZCZ-UHFFFAOYSA-N | [SMILES]
S1C=C(C2=CC=C([N+]([O-])=O)C=C2)N=C1CCl |
| Hazard Information | Back Directory | [Uses]
2-(Chloromethyl)-4-(4-nitrophenyl)-1,3-thiazole (Astragalus Polysacharin , APS) is one of the main active components of Astragalus, which has a variety of functions, including improving immune function, antioxidant, anti-radiation, anti-tumour, anti-bacterial, anti-viral and hormone-like Effects. Astragalus polysaccharides have antiviral infections, anti-tumour and neuroprotective effects, and currently, they are mainly used in biological studies, and reports indicate that astragalus polysaccharides may be candidates for the treatment of neurodegenerative diseases such as diabetic cognitive dysfunction[1-4]. | [References]
[1] ZHANG P, DENG J, WANG T, et al. Antiviral activity of Astragalus Polysacharin against PRRSV infection in vitro[J]. Research Square (Research Square), 2023, 70 1: 0. DOI:10.21203/rs.3.rs-3238215/v1.
[2] GUYUE ZHANG. Neuroprotective Effect of Astragalus Polysacharin on Streptozotocin (STZ)-Induced Diabetic Rats.[J]. Medical Science Monitor?: International Medical Journal of Experimental and Clinical Research, 2019: 135-141. DOI:10.12659/MSM.912213.
[3] XUE-NING JING. [In vitro anti-tumor effect of human dendritic cells vaccine induced by astragalus polysacharin: an experimental study].[J]. Chinese Journal of Integrated Traditional and Western Medicine, 2014, 34 9: 1103-1107.
[4] BAHARE SALEHI. Astragalus species: Insights on its chemical composition toward pharmacological applications.[J]. Phytotherapy Research, 2020. DOI:10.1002/ptr.6974.
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