ChemicalBook--->CAS DataBase List--->892742-76-6

892742-76-6

892742-76-6 Structure

892742-76-6 Structure
IdentificationBack Directory
[Name]

UYFZCWXRMHSLTC-UHFFFAOYSA-N
[CAS]

892742-76-6
[Synonyms]

UT-B-IN-1
UYFZCWXRMHSLTC-UHFFFAOYSA-N
[Molecular Formula]

C20H17N5O2S3
[MOL File]

892742-76-6.mol
[Molecular Weight]

455.576
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

UT-B-IN-1 (UTBINH-14) is a reversible, competitive and selective urea transporter-B (UT-B) inhibitor with IC50 values of 10 and 25 nM for human and mouse UT-B, respectively. UT-B-IN-1 shows low toxicity and high selectivity for UT-B over UT-A isoforms. UT-B-IN-1 increases urine output and reduces urine osmolality of mice. UT-B-IN-1 can be used for diuretic mechanism research[1].
[in vivo]

UT-B-IN-1 (300 μg; i.p., once) increases urine output and reduces urine osmolality in mice with free access to water and food[1].

Animal Model:Male mice (wild-type or UT-B knockout)[1]
Dosage:300 μg
Administration:Intraperitoneal injection, 300 μg, once
Result:Reduced urine osmolality and urea concentration in wild-type mice with V2-receptor agonist dDAVP injection. Increased urine volume and reduced urine osmolality and urea concentration in mice with free access to food and water but without dDAVP.
[References]

[1] Yao C, et al. Triazolothienopyrimidine inhibitors of urea transporter UT-B reduce urine concentration. J Am Soc Nephrol. 2012 Jul;23(7):1210-20. DOI:10.1681/ASN.2011070751
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