| Identification | Back Directory | [Name]
4-(2-methyl-1H-imidazol-1-yl)-2,2-diphenylbutanamide hydrochloride | [CAS]
893421-54-0 | [Synonyms]
Imidafenacin hydrochloride
4-(2-methyl-1-imidazolyl)-2,2-diphenylbutanamidehydrochloride
4-(2-methyl-1H-imidazol-1-yl)-2,2-diphenylbutanamide hydrochloride | [Molecular Formula]
C20H22ClN3O | [MDL Number]
MFCD20489106 | [MOL File]
893421-54-0.mol | [Molecular Weight]
355.861 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
H2O: soluble15mg/mL, clear | [form ]
powder | [color ]
white to beige | [Water Solubility ]
H2O: 15mg/mL, clear |
| Hazard Information | Back Directory | [Uses]
Imidafenacin hydrochloride is a potent and selective inhibitor of M3 receptors with a Kb of 0.317 nM[1]. | [Biological Activity]
Imidafenacin exhibits anticholinergic properties. It also has potential therapeutic effects on prostatic hyperplasia.''Imidafenacin is a potent antimuscarinic agent th at exhibits selectivity toward muscarinic M3 receptors with Kb of 0.317 nM. Imidafenacin is used for treating overactive bladder. | [References]
[1] Miyachi H, et al. Synthesis and antimuscarinic activity of a series of 4-(1-Imidazolyl)-2,2-diphenylbutyramides: discovery of potent and subtype-selective antimuscarinic agents. Bioorg Med Chem. 1999 Jun;7(6):1151-61. DOI:10.1016/s0968-0896(99)00003-6
[2] Yamazaki T, et al. Imidafenacin has no influence on learning in nucleus basalis of Meynert-lesioned rats. Naunyn Schmiedebergs Arch Pharmacol. 2013 Dec;386(12):1095-102. DOI:10.1007/s00210-013-0910-z |
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Merck KGaA
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21-20338288 |
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www.sigmaaldrich.cn |
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