| Identification | Back Directory | [Name]
MFCD07800905 | [CAS]
893772-67-3 | [Synonyms]
MFCD07800905
10-methyl-7-(trifluoromethyl)benzo[g]pteridine-2,4-dione
10-methyl-7-(trifluoromethyl)benzo[g]pteridine-2,4-quinone
10-methyl-7-(trifluoromethyl)benzo[g]pteridine-2,4(3H,10H)-dione
Benzo[g]pteridine-2,4(3H,10H)-dione, 10-methyl-7-(trifluoromethyl)- | [Molecular Formula]
C12H7F3N4O2 | [MDL Number]
MFCD07800905 | [MOL File]
893772-67-3.mol | [Molecular Weight]
296.2 |
| Hazard Information | Back Directory | [Uses]
PLK1-IN-9 (Compound M2) is an inhibitor for polo-like kinase 1 (PLK1), that inhibits PLK proteins modified with peptides 1010pT, cdc25c and PBIP, with IC50s of 1.6, 0.8 and 1.4 μM, respectively. PLK1-IN-9 inhibits proliferations of cancer cells HeLa, HL60, SNU387/499, HepG2, exhibits cytotoxicity and induces apoptosis. PLK1-IN-9 inhibits tumor growth in HepG2 xenograft mouse model[1]. | [References]
[1] Kin K, et al., Pharmaceutical composition for preventing or treating cancer, containing activation inhibitor of plk1 as active ingredient. WO2020111325. |
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| Company Name: |
Matrix Scientific
|
| Tel: |
803 788-9494 All other calls |
| Website: |
www.matrixscientific.com |
| Company Name: |
Fluorochem Ltd
|
| Tel: |
(01457) 868921 (4 lines) |
| Website: |
www.fluorochem.co.uk |
|