| Chemical Properties | Back Directory | [Boiling point ]
448.793±45.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.390±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
12.778±0.46(predicted) |
| Hazard Information | Back Directory | [Uses]
MAO-B-IN-37 (Compound 37) is a derivative of TT01001 (HY-114520), and a selective inhibitor for monoamine oxidase B (MAO-B) with an IC50 of 270 nM. MAO-B-IN-37 exhibits good metabolic stability in mice microsomes and good affinity with human serum albumin[1]. | [IC 50]
MAO-B: 0.27 μM (IC50); MAO-A: 16 μM (IC50) | [References]
[1] Barbosa Belchior M, et al., Synthesis and evaluation of enzyme inhibition by novel TT01001 derivatives as monoamine oxidase B inhibitors. Bioorg Med Chem Lett. 2024 Dec 2;117:130045. DOI:10.1016/j.bmcl.2024.130045 |
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