| Chemical Properties | Back Directory | [Appearance]
Pale Yellow Semi-Solid | [Melting point ]
71-77°C | [Boiling point ]
433.4±30.0 °C(Predicted) | [density ]
1.682±0.06 g/cm3(Predicted) | [solubility ]
Dichloromethane | [form ]
Pale Yellow Semi-Solid | [pka]
4.27±0.10(Predicted) |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Yellow Semi-Solid | [Description]
3-(2-bromoacetamido)propanoic acid is a compound containing a bromide group and a terminal carboxylic acid. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Uses]
N-Bromoacetyl-β-alanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Bromoacetyl-β-alanine is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. | [IC 50]
Alkyl-Chain; Cleavable Linker | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005
[2] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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Energy Chemical
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Aobolihui
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