| Identification | Back Directory | [Name]
1-Piperazineacetamide, 4-(2,3-dimethylphenyl)-N-(2-ethoxyphenyl)- | [CAS]
896203-18-2 | [Synonyms]
PPZ2
PPZ-2
PPZ 2
1-Piperazineacetamide, 4-(2,3-dimethylphenyl)-N-(2-ethoxyphenyl)- | [Molecular Formula]
C22H29N3O2 | [MDL Number]
MFCD05069627 | [MOL File]
896203-18-2.mol | [Molecular Weight]
367.48 |
| Chemical Properties | Back Directory | [Boiling point ]
556.0±50.0 °C(Predicted) | [density ]
1.132±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 5mg/mL, clear (warmed) | [form ]
powder | [pka]
14.02±0.70(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Description]
PPZ2 is a novel activator of DAG-activated TRPC3/TRPC6/TRPC7 channels. | [Uses]
PPZ2 is a diacylglycerol (DAG)-activated TRPC3/TRPC6/TRPC7 channel activator with activity in promoting neuronal development and survival. PPZ2 activates recombinant TRPC3/TRPC6/TRPC7 channels in a dose-dependent manner without affecting other TRPC channels. PPZ2 elicits cation currents and calcium ion (Ca(2+)) influx in cultured central neurons. PPZ2 is able to induce BDNF-like neurite outgrowth and neuroprotection, an effect that disappears after TRPC3/TRPC6/TRPC7 knockdown or inhibition. PPZ2 also increases the activation of the calcium-dependent transcription factor cAMP response element binding protein. The effects of PPZ2 suggest that calcium signaling mediated by activation of DAG-activated TRPC channels plays an important role in its neurotrophic effects[1]. | [References]
[1] Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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