| Identification | Back Directory | [Name]
Brinazarone | [CAS]
89622-90-2 | [Synonyms]
SR 33287
Brinazarone
Methanone, [4-[3-[(1,1-dimethylethyl)amino]propoxy]phenyl][2-(1-methylethyl)-3-indolizinyl]- | [Molecular Formula]
C25H32N2O2 | [MDL Number]
MFCD00865876 | [MOL File]
89622-90-2.mol | [Molecular Weight]
392.53 |
| Hazard Information | Back Directory | [Uses]
Brinazarone (SR 33287) is an inhibitor for acid lysosomal sphingomyelinase, and leads to cellular lipidosis. Brinazarone potentiates the cytotoxic effects of anti-Thy 1.2 AT15E RTA-IT on T2 cells and anti-CD5 T101 on CEM cells[1]. | [References]
[1] Jaffrézou JP, et al., In vitro and in vivo enhancement of ricin-A chain immunotoxin activity by novel indolizine calcium channel blockers: delayed intracellular degradation linked to lipidosis induction. Cancer Res. 1992 Mar 1;52(5):1352-9. PMID:1737397 |
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