| Identification | Back Directory | [Name]
3-(BENZYLOXY)AZETIDINE BENZENESULFONATE | [CAS]
897019-59-9 | [Synonyms]
3-phenylmethoxyazetidine
3-(Benzyloxy)azetidine, HCl
3-(PhenylMethoxy)-azetidine HCl
3-(BENZYLOXY)AZETIDINE BENZENESULFONATE
3-(Phenylmethoxy)-azetidinehydrochloride
3-(Benzyloxy)azetidine benzenesulfonic acid salt | [Molecular Formula]
C10H14ClNO | [MDL Number]
MFCD09907646 | [MOL File]
897019-59-9.mol | [Molecular Weight]
199.68 |
| Chemical Properties | Back Directory | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [Appearance]
White to off-white Solid | [InChI]
InChI=1S/C10H13NO.ClH/c1-2-4-9(5-3-1)8-12-10-6-11-7-10;/h1-5,10-11H,6-8H2;1H | [InChIKey]
BQTSSUSLZRYTQB-UHFFFAOYSA-N | [SMILES]
O(C1CNC1)CC1C=CC=CC=1.Cl |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 3-(benzyloxy)azetidine-1-carboxylic acid tert-butyl ester from 3-(benzyloxy)azetidine-1-carboxylic acid: tert-butyl ester of 3-(benzyloxy)azetidine-1-carboxylic acid (1.0 g) was placed in a round-bottomed flask, methanol-HCl solution (15 ml, 20%) was added, and the reaction was stirred for 1 h at room temperature. The reaction progress was monitored by thin layer chromatography (TLC). After completion of the reaction, the solvent was evaporated under reduced pressure to give the crude product as a white solid. The crude product was washed several times with ethyl acetate and dried thoroughly to afford the target compound 3-(benzyloxy)azetidine hydrochloride as a white solid in 92% yield, which can be used for subsequent reactions without further purification. | [References]
[1] Patent: WO2012/83246, 2012, A1. Location in patent: Page/Page column 46
[2] Patent: US9388164, 2016, B2. Location in patent: Page/Page column 74; 75
[3] Organic Letters, 2017, vol. 19, # 9, p. 2270 - 2273
[4] Patent: WO2017/202704, 2017, A1. Location in patent: Page/Page column 44; 45 |
|
|