| Identification | Back Directory | [Name]
Benzeneacetamide, 2-chloro-6-fluoro-N-[3-(4-fluorophenyl)-4-(4-pyrimidinyl)-5-isoxazolyl]- | [CAS]
897644-83-6 | [Synonyms]
AKP-001
AKP 001,AKP001
Benzeneacetamide, 2-chloro-6-fluoro-N-[3-(4-fluorophenyl)-4-(4-pyrimidinyl)-5-isoxazolyl]- | [Molecular Formula]
C21H13ClF2N4O2 | [MDL Number]
MFCD30533337 | [MOL File]
897644-83-6.mol | [Molecular Weight]
426.8 |
| Hazard Information | Back Directory | [Uses]
AKP-001 is an inhibitor of p38 mitogen-activated protein kinase (p38 MAPK). AKP-001 can inhibit the production of inflammatory cytokines and can be used for research in rheumatoid arthritis and inflammatory bowel disease[1]. | [References]
[1] Hasumi K, et al. Design and synthesis of 5-[(2-chloro-6-fluorophenyl)acetylamino]-3-(4-fluorophenyl)-4-(4-pyrimidinyl)isoxazole (AKP-001), a novel inhibitor of p38 MAP kinase with reduced side effects based on the antedrug concept. Bioorg Med Chem. 2014 Aug 1;22(15):4162-76. DOI:10.1016/j.bmc.2014.05.045 |
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