| Identification | Back Directory | [Name]
INZ-1 | [CAS]
897776-15-7 | [Synonyms]
INZ-1
T27617
Inz 1,Fungal,Inz-1,inhibit,yeast,Fluconazole,antifungal,Candida albicans,drug-resistance,Cytochrome P450,Inhibitor,cell,CYPs,Cytochrome Bc 1,Inz1 | [Molecular Formula]
C16H14N2O2 | [MOL File]
897776-15-7.mol | [Molecular Weight]
266.29 |
| Chemical Properties | Back Directory | [Boiling point ]
437.8±28.0 °C(Predicted) | [density ]
1.19±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
powder | [pka]
0.85±0.50(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
Inz-1 is a potent and selective mitochondrial cytochrome bc1 inhibitor for yeast (IC50=8.092 μM) over humans (IC50=45.320 μM). Inz-1 reverses Fluconazole (HY-B0101) or other triazole antifungals’ resistance in the pathogenic fungus Candida albicans[1]. | [Definition]
ChEBI: 2-(3-phenyl-1-indazolyl)acetic acid methyl ester is an alpha-amino acid ester. | [References]
[1] Benjamin M Vincent, et al. A Fungal-Selective Cytochrome Bc 1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance.Cell Chem Biol. 2016 Aug 18;23(8):978-991. DOI:10.1016/j.chembiol.2016.06.016 |
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