| Identification | Back Directory | [Name]
PF-622 | [CAS]
898235-65-9 | [Synonyms]
PF-622
FAAH Inhibitor, PF-622
N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carboxamide
1-Piperazinecarboxamide, N-phenyl-4-(2-quinolinylmethyl)- | [Molecular Formula]
C21H22N4O | [MDL Number]
MFCD10567108 | [MOL File]
898235-65-9.mol | [Molecular Weight]
346.43 |
| Chemical Properties | Back Directory | [storage temp. ]
RT | [solubility ]
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 3 mg/ml). | [form ]
Off-white solid. | [color ]
White | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| Hazard Information | Back Directory | [Description]
PF-622 (898235-65-9) is a potent and selective irreversible FAAH inhibitor. Covalently modifies active site-serine (IC50=33 nM). Completely selective for FAAH relative to other mammalian serine hydrolases. Cell permeable | [in vitro]
pf-622 inhibited the activity of faah in a time-dependent manner with the ic50 values of 0.99 and 0.033 μm in human recombinant faah for 5 and 60 minutes, respectively [1]. in various human and murine tissue proteome samples, pf-622 showed highly selectivity for faah in relative to other serine hydrolases, showing no discernable off-site activity up to 500 μm [1]. pf-622 at 1 μm decreased il-2 production in both healthy subjects and in hcv patients [2]. | [References]
1) Ahn et al. (2007), Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity; Biochemistry, 46 13019 |
|
| Company Name: |
Creative Enzymes
|
| Tel: |
1-516-855-7709 |
| Website: |
www.creative-enzymes.com |
|