| Identification | Back Directory | [Name]
2-BenzofurancarboxaMide, N-[4-[4-(3-Methylphenyl)-1-piperazinyl]butyl]- | [CAS]
898532-85-9 | [Synonyms]
2-BenzofurancarboxaMide, N-[4-[4-(3-Methylphenyl)-1-piperazinyl]butyl]-
N-[4-[4-(3-methylphenyl)piperazin-1-yl]butyl]-1-benzofuran-2-carboxamide | [Molecular Formula]
C24H29N3O2 | [MOL File]
898532-85-9.mol | [Molecular Weight]
391.506 |
| Hazard Information | Back Directory | [Uses]
D3/5-HT receptor modulator-1 (compound 5i) is a selective dopamine D3 receptor and 5-HT2A receptor antagonist and a partial 5-HT1A receptor agonist. D3/5-HT receptor modulator-1 shows Ki values of 4.5 nM, 11.9 nM, and 15.3 nM for dopamine D3, 5-HT2A, and 5-HT2A receptors. D3/5-HT receptor modulator-1 has a low affinity for dopamine D2 receptors, 5-HT2C receptors, and hERG channels. D3/5-HT receptor modulator-1 has an atypical antipsychotic profile[1]. | [IC 50]
D3 Receptor: 4.5 nM (Ki); 5-HT1A Receptor: 11.9 nM (Ki); 5-HT2A Receptor: 15.3 nM (Ki); 5-HT2C Receptor: 206 nM (Ki); D2 Receptor: 263 nM (Ki); D1 Receptor: 3290 nM (Ki); hERG Channels: 930 nM (Ki) | [References]
[1] Butini S, et al. Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior. J Med Chem. 2009 Jan 8;52(1):151-69. DOI:10.1021/jm800689g |
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