| Identification | Back Directory | [Name]
3,5,9-Trioxa-4-phosphapentacosan-1-aminium, 7-(3-carboxy-1-oxopropoxy)-4-hydroxy-N,N,N-trimethyl-10-oxo-, inner salt, 4-oxide, (7R)- | [CAS]
89947-80-8 | [Synonyms]
3,5,9-Trioxa-4-phosphapentacosan-1-aminium, 7-(3-carboxy-1-oxopropoxy)-4-hydroxy-N,N,N-trimethyl-10-oxo-, inner salt, 4-oxide, (7R)- | [Molecular Formula]
C28H54NO10P | [MOL File]
89947-80-8.mol | [Molecular Weight]
595.71 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [form ]
Solid | [color ]
White to off-white | [InChIKey]
GEUVQGBCEQLWKK-RUZDIDTESA-N | [SMILES]
[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCC(O)=O)=O)COC(CCCCCCCCCCCCCCC)=O)=O |
| Hazard Information | Back Directory | [Uses]
1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine is a glycerophosphorylcholine, consisting of glycerol phosphate, choline and palmitic acid. It accumulates in vivo at sites of oxidative stress. 1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine may be a ligand of scavenger receptors class B, while oxidized phospholipids oxPC(CD36) are potent ligands of scavenger receptors class B (CD36 and SR-BI). Oxidized phospholipids (oxPLs) also play an important role in tumor apoptosis, may be elevated in malignant biliary strictures[1][2]. | [References]
[1] Navaneethan U, et al Lipidomic profiling of bile in distinguishing benign from malignant biliary strictures: a single-blinded pilot study. Am J Gastroenterol. 2014 Jun;109(6):895-902. DOI:10.1038/ajg.2014.60
[2] Gao D, et al. Structural basis for the recognition of oxidized phospholipids in oxidized low density lipoproteins by class B scavenger receptors CD36 and SR-BI. J Biol Chem. 2010 Feb 12;285(7):4447-54. DOI:10.1074/jbc.M109.082800 |
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| Company Name: |
Merck KGaA
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21-20338288 |
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www.sigmaaldrich.cn |
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