| Identification | Back Directory | [Name]
(4'-METHYLBIPHENYL-3-YL)-METHANOL | [CAS]
89951-79-1 | [Synonyms]
AKOS BAR-1215
RARECHEM AL BD 1348
3-(4-Tolyl)benzyl alcohol
(4'-METHYLBIPHENYL-3-YL)-METHANOL
4'-Methyl[1,1'-biphenyl]-3-methanol
(4'-METHYL[1,1'-BIPHENYL]-3-YL)METHANOL
(4'-Methyl-[1,1'-biphenyl]-3-yl)methanol | [Molecular Formula]
C14H14O | [MDL Number]
MFCD05981708 | [MOL File]
89951-79-1.mol | [Molecular Weight]
198.26 |
| Questions And Answer | Back Directory | [Synthesis]
 To a suspension of potassium flfluoride (350 mg, 6.0 mmol, spray dried) in DMF (50 mL) were added ethyldiflfluoro-(4-methyl)silane (560 mg, 3.0 mmol), 3-iodobenzyl alcohol (250 mg, 2.0 mmol), and (η3 -C3H5PdCl)2 (37 mg, 0.1 mmol). The resulting mixture was stirred at 100 °C for 15 h, cooled to room temperature, poured into saturated aqueous sodium bicarbonate solution, and extracted with diethyl ether (3 × 20 mL). The combined ethereal layer was then dried over magnesium sulfate. The solvent was removed under reduced pressure. The crude material was purifified by silica gel chromatography eluting a mixture of hexane:EtOAc (5:1) to give 340 mg (86%) of 3-hydroxymethyl-4´-methylbiphenyl as a colorless solid.Reference: Hatanaka, Y; Goda, K.; Okahara, Y.; Hiyama, T. Tetrahedron 1994, 50, 8301−8316. |
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