| Identification | Back Directory | [Name]
5-ethyl-N-[2-fluoro-5-(2-methyl-4-oxoquinazolin-3-yl)phenyl]thiophene-2-sulfonamide | [CAS]
899758-61-3 | [Synonyms]
GSK223
GSK-223
GSK 223
5-ethyl-N-[2-fluoro-5-(2-methyl-4-oxoquinazolin-3-yl)phenyl]thiophene-2-sulfonamide | [Molecular Formula]
C21H18FN3O3S2 | [MOL File]
899758-61-3.mol | [Molecular Weight]
443.514 |
| Hazard Information | Back Directory | [Description]
GSK223 is an inhibitor of iE-DAP-stimulated IL-8 release via the NOD1 signaling pathway. | [Uses]
GSK223 is a quinazolinone NOD1 pathway inhibitor with potential anti-inflammatory activity. GSK223 can selectively inhibit IL-8 release under iE-DAP stimulation without affecting IL-8 secretion caused by TNF receptor, TLR2 or NOD2 agonists. GSK223 does not directly inhibit RIP2 kinase activity. | [References]
[1] Identification of Selective Small Molecule Inhibitors of the Nucleotide-Binding Oligomerization Domain 1 (NOD1) Signaling Pathway |
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