| Identification | Back Directory | [Name]
N-[2-[[(1S)-2'-(3-Methylbutoxy)[1,1'-binaphthalen]-2-yl]oxy]acetyl]-D-lysyl-D-arginyl-L-leucine 3-methylbutyl ester hydrochloride | [CAS]
900814-48-4 | [Synonyms]
CS-879
CS-1218
AVX 13616
Isopentyl (2-(((S)-2'-(isopentyloxy)-[1,1'-binaphthalen]-2-yl)oxy)acetyl)-D-lysyl-D-arginyl-L-leucinate dihydrochloride
N-[2-[[(1S)-2'-(3-Methylbutoxy)[1,1'-binaphthalen]-2-yl]oxy]acetyl]-D-lysyl-D-arginyl-L-leucine 3-methylbutyl ester hydrochloride
N-[2-[[(1S)-2'-(3-Methylbutoxy)[1,1'-binaphthalen]-2-yl]oxy]acetyl]-D-lysyl-D-arginyl-L-leucine 3-methylbutyl ester hydrochloride USP/EP/BP | [Molecular Formula]
C50H71N7O7.2(HCl) | [MDL Number]
MFCD28053484 | [MOL File]
900814-48-4.mol | [Molecular Weight]
919 |
| Hazard Information | Back Directory | [Uses]
AVX 13616 shows the potent in vivo antibacterial activity of Avexa’s lead antibacterial candidate; particularly against drug-resistant Staphylococcus pathogens.
IC50 value: 2-4 ug/ml (MICs)
Target: antibacterial agent
AVX13616 was as active as mupirocin in a nasal decolonization model but required only a single application. The compounds are being developed for topical indications and/or wound infection/catheter-related infections. AVX13616 and other compounds showed broad spectrum antibacterial activity against a range of isolates with MICs of 2-4 micrograms per millilitre against S. aureus, coagulase negative staphylococci, enterococci, MRSA, VISA and VRSA. A single application of 5% (w/w) AVX13616 (approximately equimolar to 2% mupirocin) was as effective as 2% mupirocin administered twice a day for five days in nasal decolonisation of MRSA in mice. | [References]
[1] Avexa Presents Data from Apricitabine and Antibacterial Programs at two International Conferences |
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| Company Name: |
BOC Sciences
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1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
SPIRO PHARMA
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www.spiropharma.com.cn |
| Company Name: |
Musechem
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+1-800-259-7612 |
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www.musechem.com |
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Cckinase, Inc.
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+1 (732)236-3202 |
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www.cckinase.com |
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