| Identification | Back Directory | [Name]
GSK5959 | [CAS]
901245-65-6 | [Synonyms]
GSK5959
CS-1636
BRPF1-IN-3
GSK-5959;GSK5959
N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-piperidinyl)-1H-benzimidazol-5-yl]-2-methoxybenzamide
Benzamide, N-[2,3-dihydro-1,3-dimethyl-2-oxo-6-(1-piperidinyl)-1H-benzimidazol-5-yl]-2-methoxy- | [Molecular Formula]
C22H26N4O3 | [MDL Number]
MFCD14744183 | [MOL File]
901245-65-6.mol | [Molecular Weight]
394.47 |
| Chemical Properties | Back Directory | [Boiling point ]
527.3±50.0 °C(Predicted) | [density ]
1.263±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 13 mg/mL (32.96 mM; Need ultrasonic and warming) | [form ]
Powder | [pka]
13.06±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
GSK 5959 exhibits >100-fold selectivity for BRPF1 (IC50 = 80 nM) over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains. Inhibits BRPF1 interaction with histone H3.3, which is involved in the epigenetic regulation of gene expression and have been implicated in human cancer. | [Uses]
GSK5959 is as elective BRPF1 bromodomain inhibitor. | [storage]
Store at -20°C |
|
| Company Name: |
D&C Chemicals
|
| Telephone: |
+86-21-58447131 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList16963/0_EN.htm |
| Company Name: |
Twochem Co.Ltd.
|
| Telephone: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
|