| Identification | Back Directory | [Name]
8-Bromo-7-quinolinol | [CAS]
90224-71-8 | [Synonyms]
8-Bromo-7-quinolinol
8-broMoquinolin-7-ol
7-Quinolinol, 8-bromo-
8-Bromo-7-hydroxyquinoline
7-Hydroxy-8-bromo-quinoline
8-Bromo-7-quinolinol ISO 9001：2015 REACH | [Molecular Formula]
C9H6BrNO | [MOL File]
90224-71-8.mol | [Molecular Weight]
224.05 |
| Chemical Properties | Back Directory | [Melting point ]
196-198℃ | [density ]
1.705 | [storage temp. ]
2-8°C | [form ]
powder | [color ]
light brown | [InChI]
InChI=1S/C9H6BrNO/c10-8-7(12)4-3-6-2-1-5-11-9(6)8/h1-5,12H | [InChIKey]
ACQSKLVTXZNXGL-UHFFFAOYSA-N | [SMILES]
N1C2C(=CC=C(O)C=2Br)C=CC=1 |
| Hazard Information | Back Directory | [Synthesis]
Step 2: Synthesis of 8-bromo-7-hydroxyquinoline
A solution of bromine (22.9 mL, 0.444 mol) in acetic acid (120 mL) was slowly added dropwise to a stirred mixture of 7-hydroxyquinoline (59.0 g, 0.406 mol) in acetic acid (120 mL) and dichloromethane (240 mL), and the internal temperature of the reaction system was controlled to be at 0-5 °C. The resulting suspension was continued to be stirred at 0-5 °C for 2 h. Upon completion of the reaction, it was diluted with ethyl acetate (100 mL) and filtered. The solid product was collected, washed with ethyl acetate (2 x 20 mL) and subsequently dried under vacuum to afford 8-bromo-7-hydroxyquinoline (65 g, 76% yield). | [References]
[1] Patent: WO2010/54006, 2010, A1. Location in patent: Page/Page column 52-53
[2] Yakugaku Zasshi, 1955, vol. 75, p. 28
[3] Chem.Abstr., 1956, p. 1021 |
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| Company Name: |
Pharmalego Gold
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18321033991 |
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https://cn.pharmalego.com/ |
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