| Identification | Back Directory | [Name]
3(2H)-Pyridazinone, 4-(4-chlorophenyl)-2-[2-[4-(3-chlorophenyl)-1-piperazinyl]-2-oxoethyl]-6-(4-morpholinyl)- | [CAS]
902456-47-7 | [Synonyms]
Sirt2-IN-5
3(2H)-Pyridazinone, 4-(4-chlorophenyl)-2-[2-[4-(3-chlorophenyl)-1-piperazinyl]-2-oxoethyl]-6-(4-morpholinyl)- | [Molecular Formula]
C26H27Cl2N5O3 | [MOL File]
902456-47-7.mol | [Molecular Weight]
528.43 |
| Chemical Properties | Back Directory | [Melting point ]
230 °C(Solv: acetone (67-64-1); water (7732-18-5)) | [Boiling point ]
724.6±70.0 °C(Predicted) | [density ]
1.40±0.1 g/cm3(Predicted) | [pka]
1.85±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
Sirt2-IN-5 is a potent SIRT2 inhibtor[1]. | [IC 50]
SIRT2 | [References]
[1] Sukuroglu, M.K., et al. The potential of 4-aryl-6-morpholino-3(2H)-pyridazinone-2-arylpiperazinylacetamide as a new scaffold for SIRT2 inhibition: in silico approach guided by pharmacophore mapping and molecular docking. Med Chem Res 30, 1915–1924 (2021). |
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