902464-46-4

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902464-46-4 Structure

Identification	Back Directory
[Name] UBP310
[CAS] 902464-46-4
[Synonyms] UBP310 (S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxy-thiophene-3-yl-methyl)-5-methylpyrimidine-2,4-dione
[Molecular Formula] C14H14N3O6S+
[MDL Number] MFCD12195835
[MOL File] 902464-46-4.mol
[Molecular Weight] 352.342

Chemical Properties	Back Directory
[Melting point ] 226-228 °C (decomp)(Solv: water (7732-18-5))
[Boiling point ] 615.2±65.0 °C(Predicted)
[density ] 1.564±0.06 g/cm3(Predicted)
[storage temp. ] Store at +4°C
[solubility ] DMSO: Slightly Soluble
[form ] A crystalline solid
[pka] 2.12±0.10(Predicted)
[color ] White to off-white

Hazard Information	Back Directory
[Description] UBP 310 is an antagonist of ionotropic glutamate receptor 5 (GluR5 or GluK1; K_d = 130 nM). It less potently binds GluR2 (GluA2) and GluR6 (GluK2; K_ds = 106 and 1,626 μM, respectively). UBP 310 is inactive at metabotropic GluR group I and NMDA receptors.
[Uses] UBP 310 is a GLUK5 kainate receptor antagonist.
[storage] Store at -20°C
[References] [1] PALMI T ATLASON. Mapping the ligand binding sites of kainate receptors: molecular determinants of subunit-selective binding of the antagonist [3H]UBP310.[J]. ACS Applied Electronic Materials, 2010: 1036-1045. DOI: 10.1124/mol.110.067934 [2] MARK L MAYER. Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists.[J]. ACS Applied Energy Materials, 2006: 2852-2861. DOI: 10.1523/jneurosci.0123-06.2005 [3] DAVID PERRAIS . Antagonism of recombinant and native GluK3-containing kainate receptors[J]. Neuropharmacology, 2009, 56 1: Pages 131-140. DOI: 10.1016/j.neuropharm.2008.08.002 [4] MEI DU V J Anu Rambhadran. Luminescence resonance energy transfer investigation of conformational changes in the ligand binding domain of a kainate receptor.[J]. The Journal of Biological Chemistry, 2008, 283 40: 27074-27078. DOI: 10.1074/jbc.m805040200

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